Check-in: 9th week of GSoC (Jul 22 - Jul 28)

JoseAlanis
Published: 07/29/2019

1. What did you do this week?

This week I was able to make some good progress on the group-level inference part for my GSoC project.

This included:

  • Estimate group-levels effects of a continuous variable for the full data space using linear-regression.
    • First, this approach required the fitting of a linear regression model for each subject in the data set (i.e., first level analysis) and extracting the estimated beta-coefficients for the variabale in question. This part of the analysis picked up on the tools we've been working during the last few weeks.
    • Second, with the beta-coefficents form each subject (i.e., the original betas), a bootstrap-t (or studentized bootstrap, see for instance here) was carried out. Here, t-values where calculated for each "group of betas" sampled with replacement from the original betas. These t-values where then used to estimate more robust confidence intervals and provide a measure of "significance" or consistency of the observed effects on a group level.
    • For further discussion, see this PR on GitHub.

2. What is coming up next?

Next week, I will be working on an extension of this analysis technique for other group-level hypothesis-testing scenarios that can be derived from the linear regression framework.

In addition, one challenge for the next few weeks relies on the estimation of group-level p-values (significance testing) and correcting these for multiple testing. I particular we want to use spatiotemporal clustering techniques and bootstrap to achieve this.

3. Did you get stuck anywhere?

I wouldn't say I was stuck with anything in particular. Although, understanding the bootstrap-t technique and its implementation  for the analysis of neural time-series data was somewhat challenging and required some more reading than the usual. However, after discussion and review with my mentors, I feel confident and believe our advancement are going in the right direction.

 

 

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